Maintenance pharmacological immunosuppressive strategies in renal transplantation.
نویسندگان
چکیده
منابع مشابه
[Immunosuppressive therapy in renal transplantation].
In 1960, the beneficial effect on allograft survival of 6-mercaptopurine (6-MP) was demonstrated. In 1961, azathioprine, a less toxic derivative of 6-MP, was synthesized and soon became the main form of maintenance therapy. Around the same time, clinical studies of the effects of corticosteroids on the immune system were being conducted and successful reversal of rejection with cortisone was re...
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BACKGROUND The purpose of this study was to compare the effect of triple immunosuppressive maintenance therapy (cyclosporine, azathioprine, and prednisolone) with that of double therapy (cyclosporine and prednisolone) in renal transplant patients using graft failure, mortality, and acute rejection episodes as outcome measures. METHODS A systematic overview of articles published between 1984 a...
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1. Justify the rationale for using multiple drug regimens in recipients of solid organ transplants. 2. Analyze the limitations of established immunosuppressive strategies. 3. Evaluate the relative benefits and risks of withdrawal and avoidance immunosuppressive strategies. 4. Design and implement immunosuppressive strategies aimed at decreasing toxicity and improving long-term patient outcomes....
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End-stage liver disease secondary to hepatitis C is the most common indication for liver transplantation in the USA and Europe. Its recurrence is almost universal after transplantation. In addition, the progression to fibrosis is accelerated compared to the non-transplant population. There is much debate over the most effective immunosuppressive modality and its role in the development of fibro...
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With the development of increasingly potent new immunosuppressive agents, the outcomes after renal transplantation have continued to improve. However, patients continue to require long term chronic immunosuppression. The toxicities associated with cyclosporine, azathioprine, prednisone, and anti-lymphocyte antibodies are well known; those associated with the newer agents, tacrolimus, mycophenol...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1997
ISSN: 0032-5473
DOI: 10.1136/pgmj.73.861.386